Featured Research Papers by Month


Delivering the Diagnosis of Sex Chromosome Aneuploidy

In the fall of 2018, AXYS worked with the authors of this survey/study to disseminate it as widely as possible throughout the worldwide X and Y variation community. Additionally, one of the authors, Megan Allyse, PhD, participated in both the AXYS family conference and in the AXYS Clinic & Research Consortium meetings. Her participation in these AXYS meetings added background and greater context to the development of the survey, ensuring that it addressed many of the overriding concerns and issues that the community has identified. AXYS is pleased to see that this article has been published and our board and staff will use it to help guide our ongoing efforts to improve knowledge about, and treatment for, all X and Y variations.

Featured Video of the Month


Social Anxiety, Social Cognition and Testosterone

This month’s research paper is a new study released by Dr. Sophie van Rijn from Leiden University in the Netherlands. She continues to provide more insight into the relationships between an extra x chromosome and social anxiety and social cognition, as well as the potential impact of testosterone on both of those areas. These findings can lead to more research and possible treatment alternatives that could impact quality of life. The distinction between social cognition and social anxiety is important for parents and professionals to understand.


When It’s Not Just ADHD: Uncovering Comorbid Conditions

Research has shown that a high percentage of individuals with x and y chromosome variations often have one or more characteristics associated with ADHD. Other research has shown that a high percentage of ADHD individuals may also have secondary conditions that can benefit from treatment. These conditions would include depression, anxiety, learning disabilities, language disabilities, executive function difficulties and others. This month’s featured research article provides more information about these relationships and secondary conditions.


Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement

Neuroses and neuroticism: What’s the difference?

Research Suggests a Cure for Neuroticism

The December Featured Research article is a very recent paper from the Klinefelter adult specialty clinic in Denmark. Dr. Gravholt and his team examined the relationships between personality traits, social engagement, and anxiety & depression symptoms among KS patients. Their research suggests that neuroticism may play a central role in attention switching, anxiety and depression among patients with Klinefelter syndrome. The central role of neuroticism suggests that it may be used to help identify and treat KS patients at particularly high-risk for attention switching deficits, anxiety and depression and could be very helpful in designing interventions and programs to significantly help these individuals.

We are also including several papers that may help explain more about neuroses, neuroticism and treatment suggestions.


Transitioning to Adulthood

The suggested Featured Research paper this month is actually a link to the 10-part series of booklets on the AXYS website titled Transitioning to Adulthood (located under the Resources tab). This […]