February 2020 - The Association for X and Y Chromosome Variations

The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature (Psychosocial and Quality of Life Impact)

Article Title: The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature

Authors: Hanna, Cheetham, Fearon, Herbrand, Hudson, McEleny, Quinton, Stevenson, and Wilkes

Date of Publication: November 26, 2019

“This review examines the existing psychosocial evidence around the impact of KS, exploring what we know about KS and its relevance for health care for this group.”

Rick Frith2020-02-18T11:01:00-05:00Categories: 47,XXY (Klinefelter)|Tags: Quality of life|

Sperm retrieval rates in non-mosaic Klinefelter patients undergoing testicular sperm extraction

Article Title: Sperm retrieval rates in non-mosaic Klinefelter patients undergoing testicular sperm extraction: what expectations do we have in the real-life setting?

Authors: Boeri et al

Date of Publication: January 30, 2020

“A recent meta-analysis (Corona et al, 2017) reported positive sperm retrieval rates (SRR) in 50% of patients with Klinefelter syndrome (KS) undergoing testicular sperm extraction (TESE). However, these results do not reflect the rates of SR that we observe in clinical practice. We assessed the rate and potential predictors of SR in Klinefelter patients in the real-life setting.”

Rick Frith2020-02-17T21:18:40-05:00Categories: 47,XXY (Klinefelter)|

Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia

Article Title: Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia: a systematic review and meta-analysis

Authors: Corona et al

Date of Publication: October 30, 2019

“This analysis shows that cTESE/mTESE in subjects with NOA results in SRRs of up to 50%, with no differences when cTESE was compared to mTESE. Retrieved sperms resulted in a LBR of up to 28% ICSI cycle. Although no difference between techniques was found, to conclusively clarify if one technique is superior to the other, there is a need for a sufficiently powered and well-designed randomized controlled trial to compare mTESE to cTESE in men with NOA.”

Rick Frith2020-02-17T21:17:57-05:00Categories: 47,XXY (Klinefelter)|

AXYS Welcomes New Board Member

AXYS is thrilled to announce that Justin Dausch has joined our board. Justin served as a volunteer for AXYS in the area of finance in 2019. An attorney licensed to practice in Pennsylvania and New Jersey, Justin can be called upon to guide AXYS on legal matters. His main role on the board will use his expertise on finance and compliance. “I looking forward to utilizing my professional experience to give back to the community,” said Justin.

Rick Frith2020-02-13T15:44:37-05:00Categories: All Variations|Tags: AXYS News|

Klinefelter syndrome and testosterone treatment: a national cohort study on thrombosis risk

Article Title: Klinefelter syndrome and testosterone treatment: a national cohort study on thrombosis risk

Authors: Gravholt, Chang, Christiansen, Bojesen, Juul, Münster

Date of Publication: December 11, 2019

“Klinefelter syndrome (KS), 47,XXY, can be viewed as a disease model for investigating the risk of thrombosis in male hypogonadism and the subsequent risk related to testosterone treatment. We describe rates of thrombotic risk factors, thrombosis and thrombosis mortality in KS and the association with testosterone treatment.”

Rick Frith2022-02-16T12:46:56-05:00Categories: 47,XXY (Klinefelter)|Tags: Testosterone treatment|

Monthly Archives: February 2020

The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature (Psychosocial and Quality of Life Impact)

Sperm retrieval rates in non-mosaic Klinefelter patients undergoing testicular sperm extraction

Sperm recovery and ICSI outcomes in men with non-obstructive azoospermia

AXYS Welcomes New Board Member

Klinefelter syndrome and testosterone treatment: a national cohort study on thrombosis risk