Article Title: Unveiling Psychiatric Complexities in 48,XXYY Syndrome: A Case Study
Authors: Francisco, Spar, and Napalinga
Date of Publication: August 22, 2025
“This case explores some of the comorbid psychiatric conditions considered in this patient’s presentations and reviews the existing literature to contemplate the differential diagnosis. The individual in this case exhibited behaviors linked to ASD or underlying personality disorder traits that initially complicated treatment, but with increasing familiarity and collateral history, appropriate recommendations were made. 48,XXYY syndrome warrants further interest, as it has had limited coverage in the literature. It would be valuable to examine how this patient’s psychiatric profile compares to those of patients with other extra X or Y chromosome syndromes.”