The Association for X and Y Variations (AXYS) is an advocacy, education and support organization for individuals with X and Y chromosome variations and their families.
AXYS is a nonprofit 501(c)(3) organization formed by the merger of KS&A (formerly Klinefelter Syndrome and Associates) and AAKSIS (American Association for Klinefelter Syndrome Information and Support). The XXYY Project maintains separate 501(c)(3) status but partners with AXYS on programs, administration, advocacy and support efforts.
Klinefelter Syndrome and Associates was founded in 1989 by Melissa Aylstock, the mother of an adolescent with Klinefelter syndrome. Her goal was to provide support for other families, raise awareness among the public, and promote education and research. KS&A began to include other SCA conditions, and eventually merged efforts with AAKSIS and the XXYY project to form AXYS.
The X and Y variations are also known as “supernumerary sex chromosome aneuploidy” (SCA). They include the trisomies of 47,XXY (Klinefelter syndrome), 47,XYY, and 47,XXX (Trisomy X). Also included are the more rare 48- and 49-chromosome variations 48,XXYY; 48,XXXY; 48,XXXX; 49,XXXXY; and 49,XXXXX.
The mission of AXYS is to help individuals with one or more extra X and/or Y chromosomes and their families to lead fuller, more productive lives.
AXYS fulfills this mission by satisfying previously unmet needs and improving the lives of those impacted by the X and Y chromosome aneuploidies including Klinefelter syndrome (47,XXY), Trisomy X (47,XXX), 47,XYY syndrome, 48,XXYY, and related genetic conditions through:
- Support geared to the needs of individuals, their families, and the professionals who serve them
- Education that provides current, scientifically accurate information to our constituents and to the public
- Promoting research that advances knowledge of the field
- Improving treatment options and access for those affected by the conditions
AXYS celebrates the diversity of the human family, including sex and gender, skin color, ethnicity, religion, sexual orientation, gender identity, age, socioeconomic status, physical characteristics and mental abilities.