Article Title: Demographic Composition of Participants in Sex Chromosome Aneuploidy Studies Across the Globe: A 20-Year Systematic Review
Authors: Swenson, Bothwell, Zhivotov, Sieverts, Devireddy, Shuff, Nocon, Carl, Molison, Grzybacz, Avila, Ikomi, Cohen, Svoboda, and Davis
Date of Publication: October 7, 2025
“This systematic review reveals persistent gaps in the demographic reporting and representation of participants in SCA research. Even in the United States, where population diversity is high, published studies do not reflect the expected racial, ethnic, and socioeconomic makeup of affected individuals. To ensure that research findings are equitable and clinically relevant, future studies should adopt standardized demographic reporting and prioritize inclusive enrollment strategies to reflect the full spectrum of individuals with SCAs.”