Article Title: An extra X chromosome among adult women in the Million Veteran Program: A more benign perspective of trisomy X
Authors: Davis, Teerlink, Lynch, Klamut, Gorman, Pagadala, Panizzon, Merritt, Genovese, Ross, and Hauger
Date of Publication: February 10, 2024
“…this study of predominately undiagnosed and aging women with 47,XXX in the MVP found differences in prevalence by genetic ancestry but few differences in sociodemographic, health, and wellbeing outcomes when compared with sex-, age-, and ancestry-matched controls. While existing trisomy X literature emphasizes an increased risk for multiple malformations and disorders among various organ systems, these studies have been conducted in clinically ascertained individuals. Overall, our results provide a more reassuring outlook for females with 47,XXX while also highlighting additional research needs.”