Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers
Article Title: Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers
Authors: Hasselholm, Just, Chang, Skakkebæk, and Gravholt
Date of Publication: September 1, 2025
“We demonstrated that biological aging was clearly increased in sex chromosome aneuploidies, especially TS, potentially contributing to the severely reduced lifespan. Additionally, unfavorable changes in body composition, common in both TS and KS, and in particular in the presence of hypogonadism, could result in accelerated aging—or be the result thereof.”