Diabetes

Metabolism and Type 2 Diabetes Across Life Stages in Klinefelter Syndrome: A Population-based Cohort Study

Article Title: Metabolism and Type 2 Diabetes Across Life Stages in Klinefelter Syndrome: A Population-based Cohort Study

Authors: Chang, Pedersen, Skakkebæk, Berglund, and Gravholt

Date of Publication: 2025

“The metabolic profile in men with KS is dependent on diagnosis and treatment status, with pronounced metabolic dysfunction in U-KS [undiagnosed Klinefelter syndrome]. Better diagnosis and treatment of KS are needed to alleviate metabolic dysfunction and improve survival in men with KS.”

Rick Frith2025-11-17T16:55:41-05:00Categories: 47,XXY (Klinefelter)|Tags: Diabetes, Metabolism|

Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome

Article Title: Population-based Assessment of Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome: A PEDSnet Study

Authors: Davis, Nokoff, Furniss, Pyle, Valentine, Fechner, Ikomi, Magnusen, Nahata, Vogiatzi, and Dempsey

Date of Publication: February 1, 2022

“Diabetes and cardiovascular diseases are common among men with Klinefelter syndrome (KS) and contribute to high morbidity and mortality.”

“This large, population-based cohort of youth with KS had a higher odds of most cardiometabolic-related diagnoses than matched controls.”

Rick Frith2023-01-25T12:41:07-05:00Categories: 47,XXY (Klinefelter)|Tags: Cardiometabolic, Diabetes, Metabolism|