DNA methylation

DNA hypomethylation at specific CG-sites within TRAK1 is linked to the neurocognitive profile in Klinefelter syndrome

Article Title: DNA hypomethylation at specific CG-sites within TRAK1 is linked to the neurocognitive profile in Klinefelter syndrome

Authors: Tallaksen, Hasselholm, Berletch, Filippova, Deng, Van Dyke, MacDonald, Bammler, Chang, Buskbjerg, Gravholt, Disteche, Just, and Skakkebæk

Date of Publication: September 30, 2025

“Here, we present a comprehensive and integrative analysis of the neurocognitive profile and the methylome in KS, aiming to investigate the link between specific neurocognitive traits (processing speed, working memory, visual performance, verbal memory and learning, verbal fluency and comprehension, verbal performance, and executive functions) and DNA methylation patterns, and to identify potential epigenetic biomarkers of neurocognitive function in KS.”

Rick Frith2025-12-02T16:32:44-05:00Categories: 47,XXY (Klinefelter)|Tags: DNA methylation, Neurodevelopment|

Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers

Article Title: Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers

Authors: Hasselholm, Just, Chang, Skakkebæk, and Gravholt

Date of Publication: September 1, 2025

“We demonstrated that biological aging was clearly increased in sex chromosome aneuploidies, especially TS, potentially contributing to the severely reduced lifespan. Additionally, unfavorable changes in body composition, common in both TS and KS, and in particular in the presence of hypogonadism, could result in accelerated aging—or be the result thereof.”