Psychotropic Medication Use in 48,XXYY Syndrome
Article Title: Psychotropic Medication Use in 48,XXYY Syndrome
Authors: Dreyer, Howell, Bothwell, Molison, Carl, Swenson, Davis, Decker, GALAXY consortia, and Tartaglia
Date of Publication: March 22, 2025
“While clinical guidelines for all neurodevelopmental and behavioral diagnoses generally include therapies paired with medication management when indicated, there are no guidelines to inform management of behavior and mental health challenges in 48,XXYY specifically (Blumling et al. 2020). Clinicians must rely on general guidelines for these patients, even though pathological features are distinct and differences specific to 48,XXYY may lead to variances in responses to pharmacotherapy.
To begin to address this gap, we conducted a study of psychotropic medication use and response to help guide pharmacological
management of behavioral and mental health symptoms in individuals with 48,XXYY.”