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Sibling Support

Recommended Reading: Tips From Parents and Adults for the benefit of others

Note:  These are unofficial recommendations from parents who have found these books, articles, websites and other resources helpful in some way.  When possible, we will provide an Amazon.com link for ease of purchase, a link to the description of the book, and a link to a description of the author.  Unless otherwise stated, AXYS is not involved in the sale, and we recommend that you shop around before making your purchase.

2017-08-14T16:11:30-04:00Categories: All Variations|

Parents Advocate for Son’s Educational Needs

Date of Publication: May 2017

A couple in the U.K. are fighting to help their son with 47,XYY get what he needs to be successful in school. From the original article:

“Holly Mayatt, of Sandown Road, said her son Harry, who attends All Saints Junior Academy, is struggling more and more at school due to him not being given specialist provision which she has asked for.

Harry has XYY syndrome, a rare chromosomal disorder. Symptoms may include learning disabilities and behavioural problems such as impulsivity. He also has SPD (sensory processing disorder).”

Read more

 

 

2022-03-15T13:38:47-04:00Categories: 47,XYY|Tags: |

Growing Up with XYY

Article Title: Unique – XYY

Authors: Unique – Rare Chromosome Disorder Support Group

Date of Publication: 2014

An article with general information about XYY Syndrome.

An excerpt:

“Approximately one boy in 1000 has XYY chromosomes. In the cells of their body, instead of 46 chromosomes including one X and one Y chromosome, they have one X and two Y chromosomes, making 47 in all. The impact of the extra Y chromosome is extremely variable.”

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2018-09-06T10:52:19-04:00Categories: 47,XYY|

Findings from an XYY Study

Article Title: XYY Study Day Report

Author: Unique – Rare Chromosome Disorder Support Group

Date of Publication: 2008

“Families with a son with XYY – a single extra Y chromosome – met experts and researchers at a study day in Oxford, UK in April 2008. They heard what is already known from research conducted on boys and men with XYY who were identified in the 1960s and what is starting to emerge from a follow-up study of the development of children with an extra sex chromosome, launched last summer in the UK. This study will refine and update knowledge about boys and girls aged between 4 and 16 with Triple X, XYY and XXY (Klinefelter syndrome), and in particular what is known about their behaviour and learning.”

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2018-09-12T09:46:47-04:00Categories: 47,XYY|

Brain Morphology in Children with 47,XYY Syndrome: A Voxel and Surface-based Morphomeric Study

Authors: Jean-Francois Lepage, David S. Hong, Mira Raman, Matthew Marzelli, David P.
Roeltgen, Song Lai, Judith Ross, and Allan L. Reiss.

Date of Publication: February 2014

From the abstract:

“The neurocognitive and behavioral profile of individuals with 47,XYY is increasingly
documented; however, very little is known about the effect of a supernumerary Y-chromosome on
brain development. Establishing the neural phenotype associated with 47,XYY may prove
valuable in clarifying the role of Y-chromosome gene dosage effects, a potential factor in several
neuropsychiatric disorders that show a prevalence bias towards males, including autism spectrum
disorders. Here, we investigated brain structure in 10 young boys with 47,XYY and 10 agematched
healthy controls by combining voxel-based morphometry (VBM) and surface-based
morphometry (SBM). VBM results show the existence of altered grey matter volume in the insular
and parietal regions of 47,XYY relative to controls, changes that were paralleled by extensive
modifications in white matter bilaterally in the frontal and superior parietal lobes. SBM analyses
corroborated these findings and revealed the presence of abnormal surface area and cortical
thinning in regions with abnormal grey matter and white matter volumes. Overall, these
preliminary results demonstrate a significant impact of a supernumerary Y-chromosome on brain
development, provide a neural basis for the motor, speech, and behavior regulation difficulties
associated with 47,XYY, and may relate to sexual dimorphism in these areas.”

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2017-08-14T16:30:50-04:00Categories: 47,XYY|

Sex Chromosomes and the Brain: A Study of Neuroanatomy in XYY Syndrome

Article Title: Sex chromosomes and the brain: a study of neuroanatomy in XYY syndrome

Authors: Daniel M. Bryant, Fumiko Hoeft, Song Lai, John Lackey, David Roeltgen, Judith Ross, and Allan L. Reiss

Date of Publication: December 2012

“The results suggest that genetic variations associated with XYY syndrome result in increased brain matter volumes, a finding putatively related to the increased frequency of ASDs in individuals with this condition. In addition, frontotemporal grey and white matter reductions in XYY syndrome provide a likely neuroanatomical correlate for observed language impairments.”

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2018-09-10T14:13:48-04:00Categories: 47,XYY|

An Extra X or Y Chromosome: Contrasting the Cognitive and Motor Phenotypes in Childhood in Boys with 47,XYY Syndrome or 47,XXY Klinefelter Syndrome

Article Title: An extra X or Y chromosome: contrasting the cognitive and motor phenotypes in childhood in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome

Authors: Judith L. Ross, Martha P.D. Zeger, Harvey Kushner, Andrew R. Zinn, and David P. Roeltgen

Date of Publication: 2009

“The results from these large XYY and KS cohorts have important neurocognitive and educational implications. From the neurocognitive standpoint, the presenting findings afford an opportunity to gain insights into brain development in boys with XYY and those with KS. From the educational standpoint, it is critical that boys with XYY or KS receive appropriate educational interventions that target their specific learning challenges. These findings also provide important information for counseling clinicians and families about these disorders.”

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2018-09-05T13:57:19-04:00Categories: 47,XXY (Klinefelter), 47,XYY|

General Support for Parents

Recommended Reading: Tips From Parents and Adults for the benefit of others

Note:  These are unofficial recommendations from parents who have found these books, articles, websites and other resources helpful in some way.  When possible, we will provide an Amazon.com link for ease of purchase, a link to the description of the book, and a link to a description of the author.  Unless otherwise stated, AXYS is not involved in the sale, and we recommend that you shop around before making your purchase.

2016-11-11T02:41:41-05:00Categories: All Variations|

A Review of Trisomy X (47, XXX)

Article Title: A review of trisomy X (47,XXX)

Authors: Nicole Tartaglia, Susan Howell, Ashley Sutherland, Rebecca Wilson, and Lennie Wilson

Date of Publication: May 2010

“Trisomy X is a sex chromosome anomaly with a variable phenotype caused by the presence of an extra X chromosome in females (47,XXX instead of 46,XX). It is the most common female chromosomal abnormality, occurring in approximately 1 in 1,000 female births. As some individuals are only mildly affected or asymptomatic, it is estimated that only 10% of individuals with trisomy X are actually diagnosed. The most common physical features include tall stature, epicanthal folds, hypotonia and clinodactyly. Seizures, renal and genitourinary abnormalities, and premature ovarian failure (POF) can also be associated findings. Children with trisomy X have higher rates of motor and speech delays, with an increased risk of cognitive deficits and learning disabilities in the school-age years. Psychological features including attention deficits, mood disorders (anxiety and depression), and other psychological disorders are also more common than in the general population.”

Read more

2023-01-14T17:25:56-05:00Categories: 47,XXX (trisomy x)|Tags: |

EEOC Announces Final Bipartisan Regulations for the ADA Amendments Act

These changes to US laws and regulations may be helpful to those of you who are seeking disability benefits or protections:

EEOC Announces Final Bipartisan Regulations for the ADA Amendments Act

The U.S. Equal Employment Opportunity Commission’s (EEOC) final regulations to implement the ADA Amendments Act (ADAAA) are now available on the Federal Register website. Like the law they implement, the regulations are designed to simplify the determination of who has a “disability” and make it easier for people to establish that they are protected by the Americans with Disabilities Act (ADA).

2016-11-11T02:42:04-05:00Categories: All Variations|
AXYS Logo
The Association for X and Y Chromosome Variations (AXYS) is dedicated to addressing the needs of those affected by one or more extra X and/or Y chromosomes. We are focused on sharing knowledge, offering support, and initiating action to help improve lives of individuals and families.

Our Supporters

This website was enabled by the generous support of The American Association for Klinefelter Syndrome Information and Support, in memory of Wolfram Nolten, MD, an endocrinologist whose assistance and care were a continual inspiration to the Klinefelter community.

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