Article Title: Autism spectrum disorders in XYY syndrome: two new cases and systematic review of the literature
Authors: Lucia Margari, Anna Linda Lamanna, Francesco Craig, Marta Simone, Mattia Gentile
Date of Publication: January 25, 2014
“Abnormalities of the sex chromosomes (47, XXY, 47 XYY, 45,X/46,XY mosaicism) are frequently associated with Autism Spectrum Disorders (ASD), but the male predisposition to these disorders has not been clearly explained. Previously, the role of the X chromosome was considered important in the ASD mainly because autistic symptoms were detected in genetic syndromes involving X chromosome (fragile X syndrome, Rett syndrome, Klinefelter syndrome). Instead, few studies have analyzed the possible role of the Y chromosome in the ASD.”