Article title: Cortical gray matter structure in boys with Klinefelter syndrome
Author: Foland-Ross, Gil, Shrestha, Chromik, Hong, and Reiss
Date of Publication: May 4, 2021
“…[W]e conducted a rigorous analysis of KS-associated alterations in cortical gray matter structure using a surface-based analysis of cortical volume, thickness and surface area. To control for the effects of puberty and testosterone replacement therapy, we focused on pre- or early-pubertal males who had not yet initiated hormone supplementation. We hypothesized that males with KS would exhibit reduced cortical gray matter in the insula, temporal and frontal cortices relative to TD males, as well as increased cortical gray matter in the parietal and sensorimotor regions. Additionally, we explored whether KS-associated alterations in cortical gray matter were correlated with differences in cognitive and behavioral symptoms associated with this condition.”