Article Title: Klinefelter’s syndrome (karyotype 47, XXY) and schizophrenia-spectrum pathology

Authors: Sophie van Rijn, MSc; André Aleman, PhD; Hanna Swaab, PhD; and René Kahn, PhD, MD

Date of Publication: November 2006

“Klinefelter’s syndrome, characterised by a 47, XXY chromosomal pattern, has largely been associated with physical abnormalities. Here, we report high levels of schizophrenia-spectrum pathology in 32 men with this syndrome in comparison with 26 healthy controls. This may have implications for treatment of Klinefelter’s syndrome and suggests that the X chromosome may be involved in the aetiology of schizophrenia.”

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