47,XXY (Klinefelter) Archives - Page 18 of 21 - The Association for X and Y Chromosome Variations

Hypogonadism in the Aging Male Diagnosis, Potential Benefits, and Risks of Testosterone Replacement Therapy

Article Title: Hypogonadism in the Aging Male Diagnosis, Potential Benefits, and Risks of Testosterone Replacement Therapy

Authors: Prasanth N. Surampudi, Christina Wang, and Ronald Swerdloff

Date of Publication: December 2011

“Hypogonadism in older men is a syndrome characterized by low serum testosterone levels and clinical symptoms often seen in hypogonadal men of younger age. These symptoms include decreased libido, erectile dysfunction, decreased vitality, decreased muscle mass, increased adiposity, depressed mood, osteopenia, and osteoporosis. Hypogonadism is a common disorder in aging men with a significant percentage of men over 60 years of age having serum testosterone levels below the lower limits of young male adults.”

Rick Frith2022-02-16T12:52:30-05:00Categories: 47,XXY (Klinefelter)|Tags: Testosterone treatment|

Klinefelter Syndrome – A Clinical Update

Article Title: Clinical review: Klinefelter syndrome – a clinical update

Authors: K.A. Groth, A. Skakkebæk, C. Høst, C.H. Gravholt, A. Bojesen

Date of Publication: November 1, 2012

“Recently, new clinically important information regarding Klinefelter syndrome (KS) has been published. We review aspects of epidemiology, endocrinology, metabolism, body composition, and neuropsychology with reference to recent genetic discoveries.”

Rick Frith2018-09-05T14:26:29-04:00Categories: 47,XXY (Klinefelter)|

Putting the ‘T’rouble in Testosterone Therapy?

Article Title: Putting the ‘T’rouble in Testosterone Therapy?

Author: Charles P. Vega, MD

Date of Publication: January 30, 2014

“Four in 5 men may have symptoms of testosterone deficiency, and testosterone replacement can improve body composition and metabolic outcomes related to serum glucose and cholesterol levels. In fact, some research even suggests that testosterone treatment might improve the risk for mortality among men with testosterone deficiency. However, a large new study finds a higher risk for cardiovascular disease or death associated with testosterone therapy, and it is not the first study to do so. The current review provides a balanced perspective regarding the challenging issue of testosterone deficiency and replacement among men.”

Read more (access to full article requires free Medscape registration)

Rick Frith2022-03-10T09:41:53-05:00Categories: 47,XXY (Klinefelter)|Tags: Testosterone treatment|

Morbidity in Klinefelter Syndrome: A Danish Register Study Based on Hospital Discharge Diagnoses

Article Title: Morbidity in Klinefelter Syndrome: A Danish Register Study Based on Hospital Discharge Diagnoses

Authors: Anders Bojesen, Svend Juul, Niels H. Birkebæk, and Claus H. Gravholt

Date of Publication: January 4, 2006

“Males suffering from KS experienced an increased hospitalization rate from a variety of disorders. Some are likely to be caused by hypogonadism, and some may be linked to the syndrome per se, whereas others are not readily explained. However, other factors, e.g. socioeconomic, may be involved.”

Rick Frith2018-08-12T13:00:27-04:00Categories: 47,XXY (Klinefelter)|

Clinical research: Extra X impairs awareness of others’ minds

Article Title: Clinical research: Extra X impairs awareness of others’ minds

Author: Kate Yandell

Date of Publication: June 13, 2014

“Girls and boys born with an extra X chromosome both tend to have difficulties understanding the minds of others, but for different reasons than children with autism do, according to a study published 22 March in Genes, Brain and Behavior” (Sophie van Rijn et al).

Rick Frith2018-08-12T13:11:54-04:00Categories: 47,XXX (trisomy x), 47,XXY (Klinefelter), 48,XXYY, Other Variations|

Feminized Behavior and Brain Gene Expression in a Novel Mouse Model of Klinefelter Syndrome

Article Title: Feminized behavior and brain gene expression in a novel mouse model of Klinefelter Syndrome

Authors: T.C. Ngun , N.M. Ghahramani, M.M. Creek, S.M. Williams-Burris, H. Barseghyan, Y. Itoh, F.J. Sánchez, R. McClusky, J.S. Sinsheimer, A.P. Arnold, E. Vilain

Date of Publication: June 13, 2014

“In some Klinefelter males, certain traits may be feminized or shifted from the male-typical pattern towards a more female-typical one…In sum, our results demonstrated that investigating behavioral and molecular feminization in XXY males can provide crucial information about the pathophysiology of KS and may aid our understanding of sex differences in brain and behavior.”

Rick Frith2018-08-12T13:26:27-04:00Categories: 47,XXY (Klinefelter)|

A qualitative exploration of mothers’ and fathers’ experiences of having a child with Klinefelter syndrome

Article Title: A qualitative exploration of mothers’ and fathers’ experiences of having a child with Klinefelter syndrome and the process of reaching this diagnosis

Authors: Elyssia Bourke, Pamela Snow, Amy Herlihy, David Amor and Sylvia Metcalfe

Date of Publication: May 22, 2013

“The conclusions from this study were that parents’ experiences of having a child with KS and receiving a diagnosis were complex and multifaceted. This experience was shaped by the timing of when the diagnosis was received, who provided the diagnosis, what information was provided from health-care professionals and that which parents may have encountered on the internet. The long-term experiences for parents were also impacted by the level of support they received. These findings have implications for the process by which KS is recognized by the health-care community and supports available for families.”

Rick Frith2018-08-12T13:41:43-04:00Categories: 47,XXY (Klinefelter)|

What are the treatments for symptoms in Klinefelter syndrome (KS)?

Article Title: What are the treatments for symptoms in Klinefelter syndrome (KS)?

Author: NIH

Date of Publication: December 1, 2016

“It’s important to remember that because symptoms can be mild, many males with KS are never diagnosed ore treated.

The earlier in life that KS symptoms are recognized and treated, the more likely it is that the symptoms can be reduced or eliminated. It is especially helpful to begin treatment by early puberty. Puberty is a time of rapid physical and psychological change, and treatment can successfully limit symptoms. However, treatment can bring benefits at any age.

The type of treatment needed depends on the type of symptoms being treated.”

Rick Frith2018-08-12T14:19:09-04:00Categories: 47,XXY (Klinefelter)|

Klinefelter Syndrome: The Commonest Form of Hypogonadism, but Often Overlooked or Untreated

Article Title: Klinefelter syndrome: the commonest form of hypogonadism, but often overlooked or untreated

Author: Eberhard Nieschlag

Date of Publication: May 2013

“The diagnosis of KS would be less frequently missed if doctors were more aware of, and attentive to, its key manifestations, particularly the small, firm testes, erectile dysfunction, and the comorbidities mentioned above. If the diagnosis were made more often, patients would more often be able to receive early treatment, which would improve their quality of life.”

Rick Frith2018-08-12T14:27:13-04:00Categories: 47,XXY (Klinefelter)|

Latest Testosterone Study Finds No Heart Attack Risk

Article Title: Latest Testosterone Study Finds No Heart Attack Risk

Author: Nancy A. Melville

Date of Publication: July 3, 2014

“In the latest addition to the ongoing debate over the safety of testosterone treatment, researchers report no significant increased heart attack risk in older men treated with an intramuscular form of the therapy.

The study, published online this week in the Annals of Pharmacotherapy, compared 6,355 Medicare beneficiaries treated with testosterone with 19,065 who were not, between January 1997 and December 2005, and showed no increased risk of myocardial infarction (MI) in the treatment group (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.69 – 1.02).”

Read more (requires free Medscape registration)

Rick Frith2018-09-28T10:59:51-04:00Categories: 47,XXY (Klinefelter)|