Infertility considerations in Klinefelter syndrome: From origin to management

Article Title: Infertility considerations in Klinefelter syndrome: From origin to management

Authors: Deebel, Bradshaw, and Sadri-Ardekani

Date of Publication: December 15, 2020

“Klinefelter syndrome (KS) is defined as the presence of one or more extra “X” chromosome in a male patient. It affects approximately    1 in 600 newborn males and the most common chromosomal abnormality, leading to male hypogonadism and infertility. There is a lack of data supporting best practices for KS patients’ care. In this paper we review controversial issues in KS research ranging from mechanisms of variation in KS phenotype to abnormalities resulting in reduced sperm production to successful sperm retrieval disparities after testicular sperm extraction (TESE). Translation to live birth and offspring health is also examined. Finally, medical therapies used to optimize the hormonal status and chances of fertility in KS patients are reviewed. We will also discuss the experimental spermatogonial stem cell (SSC) treatments, which are considered the future for TESE negative patients.”

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2020-12-30T16:38:11-05:00Categories: 47,XXY (Klinefelter)|Tags: |

Fertility management of Klinefelter syndrome

Article Title: Fertility management of Klinefelter syndrome

Authors: Fainberg, Hayden and Schlegel

Date of Publication: October 7, 2019

“Individuals with KS have a relatively good prognosis for sperm recovery compared to other men with idiopathic NOA. Surgical success is heavily dependent upon surgical technique and the experience of the andrology/embryology team tasked with the identification and use of testicular sperm.”

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2020-07-28T13:00:03-04:00Categories: 47,XXY (Klinefelter)|Tags: |

When to Ask Male Adolescents to Provide Semen Sample for Fertility Preservation?

Article Title: When to ask male adolescents to provide semen sample for fertility preservation?

Authors: Ali A. Dabaja, Matthew S. Wosnitzer, Alexander Bolyakov, Peter N. Schlegel, Darius A. Paduch

Date of Publication: March 2014

“It is appropriate to consider a request for semen specimens by masturbation from teenagers at one year and six months after the onset of puberty; the onset age of puberty plus 1.5 years is an important predictor of ejaculation and sample collection for cryopreservation.”

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2020-03-16T12:53:12-04:00Categories: 47,XXY (Klinefelter)|Tags: |

Genetic Evaluation of Male Infertility

Article Title: Genetic evaluation of male infertility

Author: Matthew S. Wosnitzer

Date of Publication: March 2014

“Men with severe oligospermia (<5 million sperm/mL ejaculate fluid) or azoospermia should receive genetic testing to clarify etiology of male infertility prior to treatment. Categorization by obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is critical since genetic testing differs for the former with normal testicular function, testicular volume (~20 mL), and follicle-stimulating hormone (FSH) (1-8 IU/mL) when compared to the latter with small, soft testes and increased FSH.”

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2020-03-16T12:54:09-04:00Categories: 47,XXY (Klinefelter)|Tags: |
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