Article Title: Fertility management of Klinefelter syndrome
Authors: Fainberg, Hayden and Schlegel
Date of Publication: October 7, 2019
“Individuals with KS have a relatively good prognosis for sperm recovery compared to other men with idiopathic NOA. Surgical success is heavily dependent upon surgical technique and the experience of the andrology/embryology team tasked with the identification and use of testicular sperm.”
Article Title: Fertility in Adolescents With Klinefelter Syndrome: A Survey of Current Clinical Practice
Authors: Zganjar, Nangia, Sokol, Ryabets, and Samplaski
Date of Publication: October 14, 2019
Article Title: Fertility Considerations in Adolescent Klinefelter Syndrome: Current Practice Patterns
Authors: Bhasin and Oates
Date of Publication: December 26, 2019
Article Title: Fertility achieved through in vitro fertilization in a male patient with 48,XXYY syndrome
Authors: De‑Feng Liu, Lian‑Ming Zhao, Kai Hong, Jia‑Ming Mao, Yu‑Zhuo Yang, Zhe Zhang, Hui Jiang
Date of Publication: October 3, 2017
Presentation slides from the 2017 AXYS Family Conference presentation:
Early Male Fertility Preservation Program for X and Y Variations (PDF)
Presented by Hooman Sadri-Ardekani, MD, PhD
Presentation slides from the 2017 AXYS Family Conference presentation:
Male Fertility in X and Y Variations: Current State-of-the-Art and Future Implications (PDF)
Presented by Akanksha Mehta, MD MS
Article Title: When to ask male adolescents to provide semen sample for fertility preservation?
Authors: Peter N. Schlegel et al
Date of Publication: March 2014
“It is appropriate to consider a request for semen specimens by masturbation from teenagers at one year and six months after the onset of puberty; the onset age of puberty plus 1.5 years is an important predictor of ejaculation and sample collection for cryopreservation.”
Article Title: Genetic evaluation of male infertility
Author: Matthew S. Wosnitzer
Date of Publication: March 2014
“Men with severe oligospermia (<5 million sperm/mL ejaculate fluid) or azoospermia should receive genetic testing to clarify etiology of male infertility prior to treatment. Categorization by obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is critical since genetic testing differs for the former with normal testicular function, testicular volume (~20 mL), and follicle-stimulating hormone (FSH) (1-8 IU/mL) when compared to the latter with small, soft testes and increased FSH.”
Article Title: Medical treatment of male infertility
Authors: Ali A. Dabaja, Peter N. Schlegel
Date of Publication: March 2014
“The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility.”
Article Title: Surgical management of male infertility: an update
Authors: Monica Velasquez, Cigdem Tanrikut
Date of Publication: March 2014
“Male factor infertility is common, affecting 7% of the total population and up to half of couples who are trying to conceive. Various surgical and reconstructive options allow biological paternity depending on the etiology of the male factor issues. This article describes historical treatments and newer approaches, discussing the role for traditional open surgery, microsurgery and robotic surgery, as well as interventional radiologic procedures in the management of male infertility.”
