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AXYS - The Association for X&Y Chromosome Variations
Helpline: 1‑267‑338‑4262 |


Fertility management of Klinefelter syndrome

Article Title: Fertility management of Klinefelter syndrome

Authors: Fainberg, Hayden and Schlegel

Date of Publication: October 7, 2019

“Individuals with KS have a relatively good prognosis for sperm recovery compared to other men with idiopathic NOA. Surgical success is heavily dependent upon surgical technique and the experience of the andrology/embryology team tasked with the identification and use of testicular sperm.”

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2020-07-28T13:00:03-04:00Categories: 47,XXY (Klinefelter)|Tags: |

When to Ask Male Adolescents to Provide Semen Sample for Fertility Preservation?

Article Title: When to ask male adolescents to provide semen sample for fertility preservation?

Authors: Peter N. Schlegel et al

Date of Publication: March 2014

“It is appropriate to consider a request for semen specimens by masturbation from teenagers at one year and six months after the onset of puberty; the onset age of puberty plus 1.5 years is an important predictor of ejaculation and sample collection for cryopreservation.”

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2023-01-06T12:12:57-05:00Categories: 47,XXY (Klinefelter)|Tags: |

Genetic Evaluation of Male Infertility

Article Title: Genetic evaluation of male infertility

Author: Matthew S. Wosnitzer

Date of Publication: March 2014

“Men with severe oligospermia (<5 million sperm/mL ejaculate fluid) or azoospermia should receive genetic testing to clarify etiology of male infertility prior to treatment. Categorization by obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is critical since genetic testing differs for the former with normal testicular function, testicular volume (~20 mL), and follicle-stimulating hormone (FSH) (1-8 IU/mL) when compared to the latter with small, soft testes and increased FSH.”

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2020-03-16T12:54:09-04:00Categories: 47,XXY (Klinefelter)|Tags: |

Medical Treatment of Male Infertility

Article Title: Medical treatment of male infertility

Authors: Ali A. Dabaja, Peter N. Schlegel

Date of Publication: March 2014

The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility.”

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2020-03-16T12:56:36-04:00Categories: 47,XXY (Klinefelter)|Tags: |

Surgical Management of Male Infertility: An Update

Article Title: Surgical management of male infertility: an update

Authors: Monica Velasquez, Cigdem Tanrikut

Date of Publication: March 2014

“Male factor infertility is common, affecting 7% of the total population and up to half of couples who are trying to conceive. Various surgical and reconstructive options allow biological paternity depending on the etiology of the male factor issues. This article describes historical treatments and newer approaches, discussing the role for traditional open surgery, microsurgery and robotic surgery, as well as interventional radiologic procedures in the management of male infertility.”

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2020-03-16T12:55:49-04:00Categories: 47,XXY (Klinefelter)|Tags: |
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