Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome
Article Title: Deep phenotypic analysis of psychiatric features in genetically defined cohorts: application to XYY syndrome
Authors: Raznahan, Rau, Schaffer, Liu, Fish, Mankiw, Xenophontos, Clasen, Joseph, Thurm, Blumenthal, Bassett, and Torres
Date of Publication: February 20, 2023
“Across the full XYY group, we find a complex correlation between psychopathology and functioning such that the most severely impacted symptom domains are not necessarily those most predictive of adaptive functioning or caregiver strain. Finally, network modelling suggests 8 main axes of psychopathology in XYY syndrome, with core roles for overall symptom scores, inattention, and social difficulties.”